hi i really hope this will answer your question for you. Basic information about Indocin (Indomethacin) Indocin (Indomethacin) is often prescribed in order to treat moderate to severe rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Indocin (indomethacin) and Indocin IV (indomethacin) for Injection is a nonsteroidal anti-inflammatory drug used to treat severe rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute gouty arthritis, bursitis, and tendinitis. Summary. Weight gain is found among people who take Indomethacin, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Methotrexate, and have Rheumatoid arthritis. Indocin and Weight Gain: An Overview There are a number of problems that have been reported in people taking Indocin ® ( indomethacin ). Gradual weight gain is one of these problems that is reported rarely. An overdose of indomethacin can cause nausea, vomiting, severe headache, dizziness, confusion, and tiredness. Severe symptoms can include numbness, tingling, and seizure. If you think you have. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Find information about common, infrequent and rare side effects of Indomethacin Oral. Along with its needed effects, indomethacin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Swelling and rapid weight gain can be seen with indomethacin consumption.In such case for treatment of your hemicranial headcahe you need to consult your neurologist for other treatment options (like naprosyn and topiramate) The later is one drug given for headache which loses weight This is a brief.