However, patients, particularly those with risk factors for statin-induced myopathy, should be warned of the potential for rhabdomyolysis and told to report immediately any muscle pain, muscle weakness or cramps, or dark urine. Crestor and leg pain may indicate that a patient has developed a serious health condition caused by this statin drug. Crestor is a cholesterol-lowering medication produced by pharmaceutical behemoth AstraZeneca. Question: I have had trouble keeping my cholesterol down. When I take Crestor, the bottoms of my feet burn and start to hurt. Crestor has been the only one that I can take for a while before it makes me sick. If your muscle cramps go away when you stop taking rosuvastatin then it is highly likely the cause of your cramps. There is a moderate interaction between baclofen and gabapentin. but this interaction should not result in symptoms such as cramps. Q: If Crestor is causing the leg cramps then what health problem can that cause? A: Crestor (rosuvastatin) is a medication used to lower bad cholesterol and to raise good cholesterol. However, it. I took Crestor for 90 days at 10mg once daily. I developed severe leg cramping, decreased energy, and became very difficult to urinate. Stopped the Crestor, and 20 days later I am almost completely back to normal. If there is any relationship beyond coincidence, perhaps it is that medications like diuretics to treat hypertension and heart disease can cause dehydration and electrolyte disturbances which can predispose one to night time cramps. Have your physician test your vitamin E levels. A 2010 review published in Medical Hypotheses suggests that statin use can cause a lowering of vitamin E levels in the blood that could result in statin myopathy, or muscle cramps. I wake up every night with terrible muscle spazms/cramps in the top of my foot. I jump out of bed and quickly the pain goes away, but again within minutes it just does it again. I take motrin or advil for the pain but it doesn’t really help much. Muscle cramps can also occur as a side effect of some drugs. Medications that can cause muscle cramps include: Furosemide (Lasix), hydrochlorothiazide (Microzide), and other diuretics ( water.