First of all, the itching isn't a side effect. Any antibiotic can cause the conditions that are favorable for yeast to grow. The itching is a symptom of the yeast infection. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Kwok on can clindamycin cause yeast infections.Can contribute toward a yeast infection by removing competing bacteria. I've taken Clindamycin and fluconazole to kill a yeast infection. But now my doctor tells me I might possibly get it back because antibiotics can cause yeast infections. I'm not even sure. But now my doctor tells me I might possibly get it back because antibiotics can cause yeast infections. What is clindamycin-oral, and how does it work (mechanism of action)? Clindamycin is an antibiotic used for treating serious infections. It is effective again several types of bacteria such as Staphylococcus aureus , Streptococcus pneumoniae , Staphylococcus epidermidis , and Propionibacterium acnes. Clindamycin is an antibiotic which is given to treat serious bacterial infections. It is useful for treating joint and bone infections (such as osteomyelitis), and infections in the abdomen. Women with bacterial vaginosis and yeast infections were given courses of oral clindamycin, vaginal metronidazole gel and vaginally administered probiotics. Their partners were also given a course. infections, vaginal yeast infection, clindamycin, prescription, antibiotics, yeast infection, vagina Details: my dentist prescribed this antibiotic after a rootcanal to prevent an infection. a week later i had a vaginal yeast infection starting Clindamycin phosphate vaginal cream (Cleocin) is used to treat symptoms of bacterial vaginosis. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to using this medication. Vaginal clindamycin comes as a suppository to place in the vagina and a cream to apply to the inside of the vagina. The vaginal suppositories are usually used once a day, preferably at bedtime, for 3 days in a row. Clindamycin can also cause a more serious side effect called pseudomembranous colitis, which is an infection of the large intestine that can range in severity from mild to life-threatening.