What other drugs will affect Depakote? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. For the Consumer. Applies to divalproex sodium: oral capsule delayed release, oral tablet delayed release, oral tablet extended release. Along with its needed effects, divalproex sodium (the active ingredient contained in Depakote) may cause some unwanted effects. Depakote is a medication known as an anticonvulsant that is used to treat the manic symptoms of bipolar disorder. Learn all you need to know here DEPAKOTE ER TABLETS 2. The “ER” in Depakote ER stands for Extended Release. Available in two strengths, Depakote ER contains the same active ingredient as Depakote, (divalproex sodium) but it is designed to slowly deliver the medication over a 24-hour period. Divalproex sodium occurs as a white powder with a characteristic odor. Depakote tablets are for oral administration. Depakote tablets are supplied in three dosage strengths containing divalproex sodium equivalent to 125 mg, 250 mg, or 500 mg of valproic acid. Read about valproic acid, divalproex (Depakote, Depakote ER, Depakene, Depacon, Stavzor) a drug prescribed to treat convulsions, seizures, migraine headache, and bipolar disorder. Shakiness, nausea, drowsiness, and headaches are among the most common side effects reported with Depakote. Side effects that are less frequent but potentially serious can include unexplained bruising or bleeding, depression, and worsening of seizures. Depakote (divalproex sodium) is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches. Depakote is the brand name for divalproex sodium (also known as valproic acid), an anti-seizure drug used to treat epilepsy, some mood disorders (like bipolar disorder), and migraine headaches. Learn about Depakote® (divalproex sodium), a prescription add-on medication for epilepsy and acute bipolar mania. See if Depakote is right for you.