Cymbalta, a serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat depression, anxiety, fibromyalgia, chronic musculoskeletal pain and pain related to nerve damage from diabetes. Learn about Cymbalta (Duloxetine Hcl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathic pain. It is taken by mouth. Cymbalta Facts. Used to Treat Major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal pain Uses. Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical. Cymbalta, or Duloxetine is a serotonin-norepinephrine reuptake inhibitor used to treat depression and neurological pain. Find out about the uses and risks. Duloxetine (Cymbalta) is a moderately priced drug used to treat depression, anxiety, fibromyalgia, and nerve pain associated with diabetes (diabetic peripheral neuropathy). Doctors prescribe Cymbalta to treat depression, anxiety, and some chronic pain disorders. Research suggests that taking Cymbalta can cause modest changes in body weight. Learn more here. Cymbalta and Prozac are both approved by the U.S. Food and Drug Administration to treat depression. Cymbalta is also approved to treat generalized anxiety disorder, diabetic nerve pain and fibromyalgia, while Prozac is also approved to treat obsessive-compulsive disorder, bulimia nervosa and panic disorder. Cymbalta (Duloxetine) is used to treat depression. The drug is in a class of antidepressants called serotonin-norepinephrine reuptake inhibitors (SNRIs).