Learn about Phenergan-Codeine (Codeine Phosphate and Promethazine HCl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. PRESCRIBING INFORMATION ⓃMERSYNDOL® with codeine (acetaminophen 325 mg, codeine phosphate 8 mg and doxylamine succinate 5 mg) Analgesic, Antihistamine Learn about Tylenol-Codeine (Acetaminophen and Codeine) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Codeine is an opiate used to treat pain, as a cough medicine, and for diarrhea. It is typically used to treat mild to moderate degrees of pain. Greater benefit may occur when combined with paracetamol (acetaminophen) or a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin or ibuprofen. Evidence does not support its use for acute cough. Suspected opiate abuse, known hypersensitivity to codeine or to any of the other ingredients. In cases of liver failure, respiratory depression, or patients at risk of paralytic ileus. Acetaminophen and Codeine are supplied in tablet form for oral administration. Acetaminophen, USP, 4'-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. Medscape - Indication-specific dosing for Tylenol with Codeine, Tylenol 3 (codeine/acetaminophen), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Codeine Pharmacokinetics Absorption Bioavailability. Well absorbed following oral administration. a b e f g. Onset. Onset occurs in 15–30 minutes. a b Peak analgesic effects occur within 2 hours; g peak antitussive effects within 1–4 hours. i CYP2D6 metabolism. Codeine is metabolised by the liver enzyme CYP2D6 into morphine, its active metabolite. If a patient has a deficiency or is completely lacking this enzyme an adequate analgesic effect will not be obtained. I saw a 30 year old female who apparently developed an adverse reaction to codeine when she was 20 months old. She apparently was found with a bottle of codeine 30 mg tablets.