Clomipramine achieves its OCD and depression-reducing effects by increasing the expression of the neurotransmitters serotonin and norepinephrine in the brain. These two critical neurotransmitters are essential to mental health and are closely linked to depression and obsessive-compulsive behaviors. Your doctor may want to take some blood tests and check your heart and blood pressure from time to time. This helps to prevent unwanted side effects. This helps to prevent unwanted side effects. Is clomipramine-oral safe to take if I'm pregnant or breastfeeding? Clomipramine has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, clomipramine should be used in pregnancy only if the benefit justifies the potential risk to the fetus. Read the Medication Guide provided by your pharmacist before you start taking clomipramine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this. How to take clomipramine. Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about clomipramine and will provide you with a full list of the side-effects which you may experience from taking it. Unlike the case of its serotonin receptor antagonism, orthostatic hypotension is a common side effect of clomipramine, suggesting that its blockade of the α 1-adrenergic receptor is strong enough to overcome the stimulatory effects on the α 1-adrenergic receptor of its NET inhibition. During this time, you should take your medication in divided doses with meals to reduce your risk of stomach upset. Maximum dosage: 200 mg per day or 3 mg/kg (whichever is less). Clomipramine comes as a capsule to take by mouth. At the beginning of treatment, clomipramine is usually taken three times a day with meals as the body adjusts to the medication. How long does it take for clomipramine to have an EFFECT on ocd, depression and anxiety? Asked 19 Sep 2013 by lalaloo123 Updated 20 September 2013 All people who take clomipramine need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.