La metoclopramide è un farmaco antiemetico (che cioè inibisce il riflesso del vomito) e gastroprocinetico, in quanto stimola e coordina la motilità del tratto superiore dell'apparato digerente. Metoclopramide is a medication used mostly for stomach and esophageal problems. It is commonly used to treat and prevent nausea and vomiting, to help with emptying of the stomach in people with delayed stomach emptying, and to help with gastroesophageal reflux disease. It is also used to treat migraine headaches. Cisapride has the potential to cause arrhythmias, particularly in susceptible patients, at higher doses and when combined with drugs or foods that inhibit its metabolism. Les interactions pharmacocinétiques Les protéines, plasmatiques ou tissulaires, sont impliquées dans le transport et la diffusion de certains médicaments. Prokinetics such as bethanechol, cisapride, domperidone, and metoclopramide are treatments for GERD. They help strengthen the lower esophageal sphincter and cause the contents of the stomach to. What other drugs will affect metoclopramide? Using metoclopramide with other drugs that make you drowsy can worsen this effect. Ask your doctor before you take opioid pain medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures. I procinetici usati in casi atonia intestinale o reflusso gastroesofageo per aumentare la motilità intestinale: cisapride, domperidone, metoclopramide, levosulpride Potential side effects of prokinetics. Prokinetics have been linked to several significant side effects, some of which are potentially fatal. For example, cisapride has been associated with fatal heart arrhythmias (abnormalities in heartbeat rhythm). Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT 4 receptor agonist and indirectly as a parasympathomimetic. Cenni storici. Il prepulsid nome commerciale della cisapride è stato oggetto di pratiche di disease mongering da parte di Johnson & Johnson per aver illegalmente ed efficacemente promosso in off-label nei bambini il farmaco, nonostante documenti aziendali interni sollevassero preoccupazioni per la sua sicurezza.