Pseudomembranous colitis has been reported with most antibacterial agents and may range in severity from mild to life-threatening, with an onset of up to two months following cessation of therapy. Hello! My doctor just prescribed Cipro 500mg 2x/day and Flagyl 250mg 3x/day. I've been in a flare for about 3-4 weeks. He said to check in next week to see how I'm doing and then he'll tell me how long I need to take them. Ulcerative colitis (UC) is a chronic inflammatory bowel disease where existing treatments have proven to result in numerous side effects. An important causal factor for the development of the disease is an autoimmune cellular response against bacteria in the colon. Inflammatory bowel disease is thought to be caused by an aberrant immune response to gut bacteria in a genetically susceptible host. The gut microbiota plays an important role in the pathogenesis and complications of the two main inflammatory bowel diseases: Crohn’s disease (CD) and ulcerative colitis. Ciprofloxacin and probiotic Escherichia coli Nissle add-on treatment in active ulcerative colitis: A double-blind randomized placebo controlled clinical trial ulcerative colitis, inflammation can develop in the pouch (pouchitis). Pouchitis is often effectively managed with antibiotics. Pouchitis is often effectively managed with antibiotics. Medication Details Dear Sir: I read with interest the study of Turunen et al. 1 reporting that addition of a 6-month ciprofloxacin (500–750 mg twice daily) treatment for ulcerative colitis improved the results of conventional therapy with mesalamine and prednisone. He has been having issues with ulcerative colitis (or so we think) for about the past 4 years. He had a colonoscopy and was diagnosed with it, although he, nor I, think that is the real issue. 1. Gastroenterology. 1998 Nov;115(5):1072-8. Long-term treatment of ulcerative colitis with ciprofloxacin: a prospective, double-blind, placebo-controlled study.