Ibuprofen is an medicine used to manage mild to moderate pain, fever, inflammation, menstrual cramps, and types of arthritis. Common side effects are drowsiness, nausea, diarrhea, constipation, and ringing in the ears. Ibuprofen is an NSAID, which can cause stomach ulcers in some people. It also interacts with many other drugs. Ask your doctor before using ibuprofen together with ethanol. Do not drink alcohol while taking ibuprofen. Alcohol can increase your risk of stomach bleeding caused by ibuprofen. Protein toxicity is the effect of the buildup of protein metabolic waste compounds due to insufficient kidney function. It can occur in people with pre-existing chronic kidney disease, or those who have lost kidney function due to age. Four Clinical Stages Acetaminophen toxicity has four clinical stages, although these stages are not absolute. In Stage I patients may be asymptomatic or have nausea, vomiting and abdominal pain. Ibuprofen is used primarily to treat fever (including post-vaccination fever), mild to moderate pain (including pain relief after surgery), painful menstruation, osteoarthritis, dental pain, headaches, and pain from kidney stones. Ibuprofen (Advil, Motrin) and meloxicam (Mobic) belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include indomethacin , nabumetone (Relafen), and several others. Sometimes, acetaminophen can be more effective than ibuprofen, and vice versa. At other times, both work equally well. But each medication has risks, and some are significant. Chronic use of ibuprofen can result in gastritis, ulceration with or without GI perforation, and/or GI bleeding, which can occur at any time, often without preceding symptoms. Ibuprofen reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). When you hear the word “overdose,” images of hard drugs or powerful prescription medications probably come to mind. And chances are, you’ve never even thought about an ibuprofen overdose, but it turns out that not only can you have too much of this relatively mild pain reliever, it can put your health in peril.