You can indeed take both of these medications at the same time, and in fact your doctor may recommend that you do so. I don't think another pain doc will take you on if you go in asking for more oxycodone. What else do you do for the pain? Pills alone are not the way to go. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Namey on can you take aspirin while on antibiotics: Yes Explains the medication naproxen (Aleve, Naprosyn, Anaprox, Naprelan) a drug used for the management of mild to moderate pain, fever, and inflammation. Article includes descriptions, uses, drug interactions, and side effects. Read more about naproxen (Aleve, Naprosyn, Anaprox, Naprelan). Yes, you can use acetaminophen and ibuprofen together. That combination of drugs controls very high fever in children. You need to know that they are not the similar drugs. My brother-in-law recently asked me if he could take Aleve (naproxen) and Motrin (ibuprofen, Advil) together. Apparently, he pulled a muscle while trying to relive the glory days of his college football playing. I agree for the most part to the answers you received, Motrin etc you can take with Subox. It is also now being given to moderate chronic pain sufferers. Aleve, aka naproxen, is an NSAID that many people with back pain take to get relief. Find out how often you can take it. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Acharya on can i take 1600 mg of ibuprofen: That would be an overdose for this medication. What other drugs will affect Motrin? Ask your doctor before using Motrin if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.