i have been taking Losartan Potassium 25 mg for 3 months and have been experiencing depression for the past month. I usually do not suffer from depression can it be the drug. Stress anxiety and adrenaline from working out can cause them to flare up but it is possible if you give your heart a bit of a break from working out too hard it will help settle down the ectopics. The heart is a muscle and just like any other muscle in your body it can get aggravated. Re: Losartan and Depression Rick, Valsartan went generic last year.it was BENICAR, an ARB that people liked more than losartan but it is not on my insurance formulary yet. Summary. Depression is found among people who take Losartan, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Amlodipine, and have High blood cholesterol. Along with its needed effects, losartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Common Questions and Answers about Losartan and depression. High BP can cause headache and dizziness and body weakness. Valsartan and losartan. Amlodipine/valsartan oral tablet may cause drowsiness, and it can also cause other side effects. More common side effects. The more common side effects. Side effects can occur during treatment with Diovan, and depression is not one of them. During. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. When grief lasts way too long, though, it can become depression in those who are prone to depression. And while anxiety is triggered by certain things for us, those things don't cause chronic anxiety -- many people go through the same things and don't develop an anxiety disorder, so it's more likely some of us just have it in us.