While you are taking St. John's wort, you must not eat or drink certain foods and beverages that are high in tyramine. Eating these foods while you are taking St. John's wort can raise your blood pressure to dangerous levels. Cymbalta, or Duloxetine is a serotonin-norepinephrine reuptake inhibitor used to treat depression and neurological pain. Find out about the uses and risks. Important Information. Many drugs can interact with St. John's wort, and serious drug interactions can occur when certain medicines are used at the same time. Cymbalta (duloxetine), a drug prescribed for neuropathic pain associated with diabetic peripheral neuropathy, depression, and anxiety. Side effect, dosage, and drug interaction information included. Consumer information about the medication DULOXETINE - ORAL (Cymbalta), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug DULOXETINE - ORAL. Cymbalta is an antidepressant approved to treat mood and pain disorders. It was one of Eli Lilly’s most profitable drugs. It works by preventing the body from reabsorbing two neurotransmitters: serotonin and norepinephrine. Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water. Each capsule contains enteric-coated pellets of 22.4, 33.7, or 67.3 mg of duloxetine hydrochloride equivalent to 20, 30, or 60 mg of duloxetine, respectively. Duloxetine oral capsule is available as both a generic and brand-name drug. Brand names: Cymbalta and Irenka. Duloxetine only comes as a capsule you take by mouth. Some of the most common Cymbalta side effects can include headaches, diarrhea, and insomnia. This eMedTV segment also takes an in-depth look at some of the more serious side effects of the drug, such as hallucinations and suicidal thoughts. Cymbalta (duloxetine) may help relieve nerve pain from diabetes and other forms of chronic pain. Cymbalta (duloxetine) has several uses, which may be good for people with multiple conditions.