Related questions; I have diarrhea with puke. Doctor have gave me imodium, (loperamide) buscopan plus, b complex, and propepsa. Alre more I have diarrhea with puke. Yes, it is okay. It is safe to take the two together. Just be aware that both medications will have the combined effect - in different ways - of reducing water in your gastrointestinal tract. Hello Everyone, Thank you so much for all replies, sometimes you feel like your on your own and it helps to know I'm not the only one. The medication I am on is Imodium and an anti-spasmodic called buscopan. I have been prescribed mebeverine and Buscopan together but I take Mebeverine 20 minutes before a meal and Buscopan when needed. Nurofen is terrible on the stomach , it can cause bleeding , I can't take it. So what my question is, is it ok to take ibuprofen, buscopan and Imodium all at the same time? All in the recommended doses. Seeing as that is all I can buy over here. Thank you All in the recommended doses. I am taking Imodium at the moment to try to stop the diarrhoea.It gives me a lot of trapped wind.It's not causing me any pain but when the pressure builds up,I pass the wind with some diarrhoea.This starts the anxiety again.If I took Buscopan,Would this allow the wind to pass with much less force?Or is there something else I could do? Summary. Drug interactions are reported among people who take Imodium and Buscopan together. This study is created by eHealthMe based on reports of 89 people who take Imodium and Buscopan from FDA, and is updated regularly. Compare Buscopan vs. Loperamide, which is better for uses like: IBS, Stomach Cramps and Ulcerative Colitis. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Loperamide 4.4/5 over Buscopan 3.7/5 in overall satisfaction. Compare Buscopan vs. Imodium, which is better for uses like: IBS, Stomach Cramps and Ulcerative Colitis. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Imodium 4.1/5 over Buscopan 3.7/5 in overall satisfaction. It's usually best not to take Buscopan together with other IBS remedies, as they work in the same way. You're unlikely to get extra relief for your symptoms, and it may cause more side effects. Take only 1 IBS remedy, unless your doctor advises otherwise.