should set a date to stop smoking and treatment with varenicline should start 1 to 2 weeks before this date and that smoking cessation therapies are more likely to succeed for patients who are provided with additional advice and support. Substantial concerns have been raised about the neuropsychiatric safety of the smoking cessation medications varenicline and bupropion. Their efficacy relative to nicotine patch largely relies on indirect comparisons, and there is limited information on safety and efficacy in smokers with psychiatric disorders. AbstractIntroduction. Bupropion and varenicline are non-nicotine medications used for smoking cessation that mitigate craving and withdrawal symptoms. We aim t La varénicline est supérieure au bupropion pour l'arrêt du tabac mais le taux de succès reste inférieur à un patient sur quatre [21]. Selon d'autres études, le taux d'arrêt du tabagisme à 52 semaines est de 19 % [ 22 ] et peut même descendre jusqu'à 14,4 % [ 23 ]. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. Linden K, Jormanainen V, Linna M, Sintonen H, Wilson K, Kotomaki T. Cost effectiveness of varenicline versus bupropion and unaided cessation for smoking cessation in a cohort of Finnish adult smokers. One reason people have been interested in adding bupropion is that it is associated with less weight gain with smoking cessation than some other agents, and there certainly was some signal of that. As of 2002 there were two case reports of people experiencing withdrawal symptoms when discontinuing bupropion taken to aid smoking cessation; the prescribing information states that dose tapering is not required when discontinuing treatment for smoking cessation. Continued Varenicline. The FDA approved varenicline (Chantix) in 2006 to help people quit smoking. Studies show that taking it makes you two to three times more likely to quit for good. Tobacco smoking is widespread and is one of the world’s most prevalent modifiable risk factors for morbidity and mortality. It is important to facilitate smoking cessation better in order to reduce the health consequences of tobacco use.