Hey guys! I'm going to point-form this because I know reading is difficult for most of us! - gradually increased concerta dose over about 6. Has anyone else built somewhat of a tolerance to concerta. I am on the 36mg and have been for a few years now. When I was first given it, it. I have not heard of tolerance buildup for Concerta, however, there are many meds that just stop working for no apparent reason. My friend's husband hit a real crisis a few years ago when the wellbutrin stopped working for him, and non of the other anti depressants had the same effect for him. I was diagnosed with ADHD in 6th grade and was prescribed concerta 18mg. When I was in 7th grade it started to lose its effects so me increased it to 24mg. Uses: Concerta is prescribed for ADHD and ADD and is mostly mentioned together with these indications. In addition, our data suggest that some patients take it for Depression and Anxiety, although this is not an approved use*. Thankfully, the Concerta my husband is taking has been working along with Wellbutrin, I believe. I heard that it is not known to build a tolerance but, people can be different. Medication tolerance: when stimulants such as Adderall, Ritalin or Vyanse stop working. Some of the reasons are discussed. We develop tolerance to Methylphenidate or other cns in your case, Ritalin with prolonged use. Ritalin is dopaminergic. Let me first explain how tolerance works, think of your dopamine receptors as gloves and the dopamine as balls. How long does it take for a tolerance to Adderall to build up?. Ask your doctor to prescribe you 18 mg Concerta to take one or two days a week when you will not consume amphetamine. Hope you will find it helpful. P.S. Other commentators wrote BS. Do not expect their answers to be true. 6k Views · View 6 Upvoters · Answer requested by. Betsy Rice. s p o n s o r e d b y C o m p a r e C a r. One of the main side effects of Concerta is Headaches. Your daughter could have just built up such a tolerance to it in her body that she is having some kind of a over dose type reaction.