View detailed reports from patients taking Sulfamethoxazole; Trimethoprim who experienced irritability. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Can Amoxicillin cause Irritability? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Bactrim Related Irritability seen in social media and in the FDA adverse event database. Summary. Irritability is found among people who take Bactrim, especially for people who are male, 60+ old , have been taking the drug for 1 month, also take medication Fluconazole, and have Multiple myeloma. Note: This document contains side effect information about sulfamethoxazole / trimethoprim. Some of the dosage forms listed on this page may not apply to the brand name Bactrim. Summary. Irritability is found among people who take Bactrim ds, especially for people who are male, 60+ old also take medication Benadryl, and have Multiple myeloma. Easy-to-read patient leaflet for Bactrim DS. Includes indications, proper use, special instructions, precautions, and possible side effects. Can Septra cause Irritability? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. BACTRIM & BACTRIM DS Overview and uses Brand name and active pharmaceutical ingredient. Bactrim – Sulfamethoxazole 400 mg + Trimethoprim 80 mg. Bactrim DS (double strength) – Sulfamethoxazole 800 mg + Trimethoprim 160 mg.