Bugs ‘N Drugs General Principles of Antimicrobial Therapy Hina N. Patel, Pharm.D., BCPS I. Basic Considerations a. Empiric treatment i. Site of infection NEW ORLEANS – National Inpatient Sample data showed that during 2004-2015 hospitalized U.S. patients with a PE diagnosis jumped by 80%. Understanding the vast world of antibiotics and anti-infectives is no easy task. Anti-infectives are a large class of drugs that cover a broad range of infections, including fungal, viral, bacterial, and even protozoal infections. …the second or third generation oral cephalosporins). Ampicillin-sulbactam is a parenteral formulation that expands the spectrum of ampicillin to include most strains of S. aureus and beta-lactamase … Recommended Antimicrobial Agents for the Treatment and Postexposure Prophylaxis of Pertussis 2005 CDC Guidelines. Prepared by Tejpratap Tiwari, M.D. The addition of azithromycin to standard regimens for antibiotic prophylaxis before cesarean delivery may further reduce the rate of postoperative infection. We evaluated the benefits and safety. We hypothesized that mass distribution of a broad-spectrum antibiotic agent to preschool children would reduce mortality in areas of sub-Saharan Africa that are currently far from meeting the. Combination therapy with a macrolide and beta-lactam (e.g. ceftriaxone plus azithromycin) is supported by the greatest volume of evidence and experience. Azithromycin, the first azalide from the macrolide class of antibiotics, has rapidly become one of the more common antibiotics prescribed by paediatricians, particularly for respiratory infections. S544 Vol. 6 (6C) June 2006 ofloxacin).3 If there was evidence or suspicion of MRSA, additional coverage would be needed until culture results were available (eg, vancomycin or line-.