Malaria is caused by a parasite called Plasmodium, which is transmitted via the bites of infected mosquitoes. In the human body, the parasites multiply in the liver, and then infect red blood cells. Package leaflet: Information for the patient. Malarone 250 mg/100 mg film-coated tablets. atovaquone/proguanil hydrochloride How to use Atovaquone-Proguanil HCL. Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication, and each time you get a refill. Comprehensive, up-to-date information on HIV/AIDS treatment and prevention from the University of California San Francisco Atovaquone/Proguanil A - Be Aware When There is a Risk However Small. Find out if there is a malaria risk in the area you are visiting. Aspects of travel may increase the risk e.g. rural travel, rainy season or unscreened accommodation. Malarone contains a combination of atovaquone and proguanil. Atovaquone and proguanil are medications used to treat malaria, a disease caused by parasites. Malaria prevention consists of a combination of mosquito avoidance measures and chemoprophylaxis. Although very efficacious, none of the recommended interventions are 100% effective. Treatment of Acute Malaria. Adults. Four Malarone tablets (adult strength; total daily dose 1 g atovaquone/400 mg proguanil hydrochloride) as a single daily dose for 3 consecutive days. DRUG 1 ADULT DOSE PEDIATRIC DOSE COMMENTS; ATOVAQUONE-PROGUANIL The adult tablet contains 250 mg atovaquone and 100 mg proguanil. The pediatric tablet contains 62.5 mg atovaquone and 25 mg proguanil. Malarone is a fixed dose combination of atovaquone and proguanil hydrochloride which acts as a blood schizonticide and also has activity against hepatic schizonts of Plasmodium falciparum.