TYLENOL® is an appropriate analgesic choice to consider for patients on aspirin heart therapy 1 Updated NSAID warnings: help your patients understand risks The U.S. Food and Drug Administration (FDA) required an update to the Drug Facts labeling of all adult and pediatric non-aspirin OTC nonsteroidal anti-inflammatory drugs (NSAIDs), for example Motrin®, Advil®, and Aleve® products. Aspirin and Tylenol (acetaminophen) are used to treat fever, and pain in the body. Aspirin is also used to prevent blood clots (antithrombotic). Aspirin and Tylenol belong to different drug classes. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and Tylenol is an analgesic (pain reliever) and antipyretic (fever reducer). Acetaminophen, the active ingredient in TYLENOL ®, can be an appropriate pain relief option for patients on aspirin heart therapy because it does not inhibit the heart-healthy benefits of your aspirin therapy and does not irritate the stomach the way that naproxen sodium or even ibuprofen can. Tylenol is often recommended as a gastric-friendly alternative to aspirin, which has a history of irritating the stomach when taken without food. It is one of the most widely used medicines in the United States, mainly for treatment of pain and fever. Daily aspirin therapy to protect the heart is not for everyone. Find out whether or not aspirin is right for you. Find out whether or not aspirin is right for you. Skip to main content As with any over the counter drugs, low-dose aspirin and Tylenol therapy can be harmful when self-prescribed. It’s more important than ever to make sure our loved ones take pain relievers safely. Aspirin has been used as a pain reliever for more than 100 years. Since the 1970s, it’s also been used to prevent and manage heart disease and stroke. Compare Aspirin vs Tylenol head-to-head for uses, ratings, cost, side effects, interactions and more. Aspirin rated 7.4/10 vs Tylenol rated 7.3/10 in overall patient satisfaction. Aspirin rated 7.4/10 vs Tylenol rated 7.3/10 in overall patient satisfaction. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) used to treat fever, pain. Aspirin is also used to treat inflammation in the body, to prevent blood clots, and to reduce the risk of strokes and heart attacks. Aspirin and Tylenol belong to different drug classes. Aspirin is a nonsteroidal Therapy with salicylates, especially aspirin, should be administered with extreme caution in patients with hypoprothrombinemia, vitamin K deficiency, thrombocytopenia, thrombotic thrombocytopenic purpura, severe hepatic impairment, or anticoagulant use.