General Pharmacology. Currently approved calcium-channel blockers (CCBs) bind to L-type calcium channels located on the vascular smooth muscle, cardiac myocytes, and cardiac nodal tissue (sinoatrial and atrioventricular nodes). The following alerts about therapeutic products have been issued by the TGA since 1998. Drug. Interaction. Comments. Amlodipine. Modest increase in atorvastatin exposure 1. Not clinically relevant 1. Antacids. Decreased plasma atorvastatin concentrations 1 Effects of other medicinal products on amlodipine. CYP3A4 inhibitors: Concomitant use of Amlodipine with strong or moderate CYP3A4 inhibitors (protease inhibitors, azole antifungals, macrolides like erythromycin or clarithromycin, verapamil or diltiazem) may give rise to significant increase in amlodipine exposure. Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Amlodipine Besylate reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). The following alerts about therapeutic products have been issued by the TGA since 1998. Amlodipine 10 mg tablets - Summary of Product Characteristics (SmPC) by Accord Healthcare Limited Valsartan, sold under the trade name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It is a reasonable initial treatment for high blood pressure. It is taken by mouth. Versions are avaliable as the combination valsartan/hydrochlorothiazide and valsartan/amlodipine. Product Information – Australia APO-AMLODIPINE 2.5 mg, 5 mg, 10 mg TABLETS NAME OF THE MEDICINE Amlodipine besylate. DESCRIPTION Amlodipine besylate is a dihydropyridine derivative.