The colized albumin replacement and contin- failure (Sepsis-related Organ Failure Assess- furosemide study drug infusion drip rate was uous infusion furosemide vs. double pla- ment [SOFA]) and lung injury (LIS) scores, titrated every 8 hrs to achieve a net diuresis cebo with targeted goals of net diuresis, and the etiology of lung injury were recorded and daily weight loss of ⱖ 1 kg/day. The. Hypoproteinemia, fluid retention, and weight gain are associated with development of acute lung injury and mortality in critically ill patients, without proof of cause and effect. Martin GS, Mangialardi RJ, Wheeler AP, et al. Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. Crit Care Med 2002;30:2175-2182 Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common, deadly, and costly. The appropriate management of fluids and the use of colloid therapy in these patients have been debated for decades and remain controversial. with contemporary approaches to optimizing therapy in this condition, including the role of albumin and diuretic therapy. Keywords - Acute lung injury, ARDS, hypoproteinaemia, extravascular lung water, intravenous fluids, colloids Conclusion. The addition of albumin to furosemide therapy in hypoproteinemic patients with acute lung injury/acute respiratory distress syndrome significantly improves oxygenation, with greater net negative fluid balance and better maintenance of hemodynamic stability. Albumin and furosemide for acute lung injury Asjad Khan, 1 Eric B. Milbrandt, 2 and Ramesh Venkataraman 2 1 Clini cal Fellow, Department of Criti a l Care Medicine, University of Pittsburgh S hool of Medicine, Pittsburgh, Pennsyvania, USA Conclusion. The addition of albumin to furosemide therapy in hypoproteinemic patients with acute lung injury/acute respiratory distress syndrome significantly improves oxygenation, with greater net negative fluid balance and better maintenance of hemodynamic stability. A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury. Crit Care Med. 2005; 33 :1681–1687. doi: 10.1097/01.CCM.0000171539.47006.02. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common, deadly, and costly. The appropriate management of fluids and the use of colloid therapy in these patients have been debated for decades and remain controversial.