Spironolactone is the generic form of the brand-name drug Aldactone, a prescription diuretic drug. The drug is used to treat a condition called primary hyperaldosteronism, in which the body. Gynecomastia is usually reversible when spironolactone is discontinued, although in rare instances some breast enlargement may persist. Adverse reactions are usually reversible upon discontinuation of the drug. Along with its needed effects, spironolactone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Our Aldactone (spironolactone) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Spironolactone drug interactions (in more detail) Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use spironolactone only for the indication prescribed. Prednisone: (Minor) The manufacturer of spironolactone lists corticosteroids as a potential drug that interacts with spironolactone. Intensified electrolyte depletion, particularly hypokalemia, may occur. However, potassium-sparing diuretics such as spironolactone do not induce hypokalemia. In fact, hypokalemia is one of the indications for potassium-sparing diuretic therapy. Therefore, drugs. Unexpected outcome (positive or negative) including adverse drug reactions Spironolactone, a possible selective androgen receptor modulator, should be used with caution in patients with metastatic carcinoma of the prostate 1. JAMA. 1973 Jul 2;225(1):40-3. Adverse reactions to spironolactone. A report from the Boston Collaborative Drug Surveillance Program. Greenblatt DJ, Koch-Weser J. In one study, 2 mg/kg PO of hydrochlorothiazide and 1.5 mg/kg PO of spironolactone every 12 hours for 8 weeks improved lung compliance, increased survival, and improved oxygenation for patients that received the diuretic combination relative to patients that received placebo.